SCREEN-WELL生物活性脂质库包含190种96孔格式的生物活性脂质。非常适合筛选或鉴定重组孤儿G蛋白偶联受体、靶标验证、二次筛选、验证新测定和常规药理学应用。
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The SCREEN-WELL® Bioactive Lipid Library contains 190 bioactive lipids in a 96 well format. Ideal for screening or identifiying recombinant orphan G protein-coupled receptors, target validation, secondary screening, validating new assays and for routine pharmacological applications.
Applications:HTS
Contents:190 compounds including: Agonists & Antagonists, Endocannabinoids, Farnesyl/geranylgeranyl derivates, HETEs deHETEs, hepoxilins, Polyunsaturated fatty acids, Leukotrienes, lipoxins, LPA & phosphatidic acids, Octadecanoids, PAFs, Prostaglandins & thromboxanes, Retinoids, vitamin D metabolites, Sphingolipids.
Quantity:100 or 500µl per well.
Concentration:DMSO solutions (1.0 or 0.1mM, depending on compound).
Use/Stability:Stable for at least one year from the date of receipt when stored at -80°C.
Long Term Storage:-80°C
SCREEN-WELL生物活性脂质库#BML-2800-0100相关参数说明:
内容:190种化合物,包括:激动剂和拮抗剂,内源性大麻素,法呢基/香叶基香叶基衍生物,HETEs deHETEs,七氧西林,多不饱和脂肪酸,白三烯,脂氧素,LPA和磷脂酸,十八烷类,PAF,前列腺素和血栓素,类维生素A,维生素D代谢物,鞘脂。
数量:每孔100或500μl。
浓度:DMSO溶液(1.0或0.1mM,取决于化合物)。
使用/稳定性:在-80°C下储存时,自收到之日起至少可稳定一年。
航运:干冰
长期储存:-80°C
RUO -仅供研究使用
SCREEN-WELL生物活性脂质库部分文献参考:
1.Molecular basis for the interaction of cellular retinol-binding protein 2 (CRBP2) with non-retinoid ligands: J. Silvaroli, et al.; J. Lipid Res. 62, 100054 (2021),
2.Mechanism of activation for the sirtuin 6 protein deacylase: M.A. Klein, et al.; J. Biol. Chem. 295, 1385 (2020),
3.Abnormal cannabidiol modulates vitamin A metabolism by acting as a competitive inhibitor of CRBP1: J.A. Silvaroli, et al.; ACS Chem. Biol. 14, 434 (2019),
4.Brown Adipogenic Reprogramming Induced by a Small Molecule: B. Nie, et al.; Cell Rep. 18, 624 (2017),
5.Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma: U.I. Scholl, et al.; J. Clin. Invest. 127, 2739 (2017),
6.AM251 Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells: T. Yoshinaga, et al.; PLoS One 11, e0167848 (2016),
7.Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells: J.H. Rhim, et al.; Sci. Rep. 6, 26547 (2016),
8.Synthetic Ligands of Cannabinoid Receptors Affect Dauer Formation in the Nematode Caenorhabditis elegans: P.R. Rodrigues, et al.; G3 (Bethesda) 6, 1695 (2016),
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